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Technical Data
| Formula | C27H24N6 |
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| Molecular Weight | 432.52 | CAS No. | 1313881-70-7 | |
| Solubility (25°C)* | In vitro | DMSO | 8 mg/mL (18.49 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Miransertib (ARQ-092) is a potent, selective and orally bioavailable allosteric inhibitor of Akt with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. | ||||||
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Protocol (from reference)
Selleck's Miransertib (ARQ-092) has been cited by 9 publications
| Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer [ Commun Biol, 2023, 6(1):916] | PubMed: 37673933 |
| Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer [ Commun Biol, 2023, 6(1):916] | PubMed: 37673933 |
| AKT mutant allele-specific activation dictates pharmacologic sensitivities [ Nat Commun, 2022, 13(1):2111] | PubMed: 35440569 |
| Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury [ Adv Sci (Weinh), 2022, e2202632] | PubMed: 36373718 |
| Revisiting the Resazurin-Based Sensing of Cellular Viability: Widening the Application Horizon [ Biosensors (Basel), 2022, 12(4)196] | PubMed: 35448256 |
| Viability fingerprint of glioblastoma cell lines: roles of mitotic, proliferative, and epigenetic targets [ Sci Rep, 2021, 11(1):20338] | PubMed: 34645858 |
| 1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice [ Food Chem Toxicol, 2021, 157:112578] | PubMed: 34560177 |
| Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury [ Int J Biol Sci, 2020, 16(14):2559-2579] | PubMed: 32792857 |
| CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways [ Neurobiol Dis, 2019, 126:47-61] | PubMed: 29944965 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.