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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C15H25NO3 |
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| Molecular Weight | 267.36 | CAS No. | 51384-51-1 | ||||
| Solubility (25°C)* | In vitro | DMSO | 53 mg/mL (198.23 mM) | ||||
| In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. | |
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Protocol (from reference)
References
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Selleck's Metoprolol Has Been Cited by 12 Publications
| A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction [ Drug Delivery, November 26 2025, 2585612] | PubMed: 41307200 |
| Screening of GPCR drugs for repurposing in breast cancer [ Frontiers in Pharmacology, December 06 2022, 1049640] | PubMed: 36561339 |
| In Vitro and In Vivo Assessment of Pharmacokinetic Profile of Peramivir in the Context of Inhalation Therapy [ Pharmaceuticals (Basel), 2025, 18(2)181] | PubMed: 40005995 |
| Species-specific in vivo exposure assessment and in vivo-in vitro correlation of the carboxylate esters prodrug HD56 targeting FK506 binding proteins: The pivotal role of humanized mice [ Drug Metab Dispos, 2025, 53(4):100049] | PubMed: 40073534 |
| SARS-CoV-2 ORF 3a-mediated currents are inhibited by antiarrhythmic drugs [ Europace, 2024, euae252] | PubMed: 39412366 |
| Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25] | PubMed: 38444002 |
| Antiviral activity evaluation of pharmaceutical drugs, newly synthesized compounds and fragments against SARS-CoV-2 in vitro [ UNIVERSITY OF PÉCS, 2023, ] | PubMed: None |
| Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch [ Cell Rep, 2022, 38(10):110468] | PubMed: 35263588 |
| Dose–Response Effects of 7-Dehydrocholesterol Reductase Inhibitors on Sterol Profiles and Vesicular Stomatitis Virus Replication [ ACS Pharmacology & Translational Science, 2022, 1086–1096] | PubMed: 36407960 |
| Screening of GPCR drugs for repurposing in breast cancer [ Frontiers in Pharmacology, 2022, 1049640] | PubMed: 36561339 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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