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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C23H22ClFN8O2 |
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| Molecular Weight | 496.93 | CAS No. | 2833703-74-3 | |
| Solubility (25°C)* | In vitro | DMSO | 62 mg/mL (124.76 mM) | |
| Ethanol | 4 mg/mL (8.04 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Vepugratinib (LOXO‑435; LY3866288) is a potent, highly isoform‑selective small‑molecule inhibitor of FGFR3 that is engineered to retain activity against FGFR3 gatekeeper mutations. It also eexhibits potential antitumor activity in FGFR3‑altered advanced solid tumors, especially metastatic urothelial cancer. |
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Protocol (from reference)
References
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