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Biological Description
| Specificity | LIMP-2/SCARB2 Rabbit mAb detects endogenous levels of total LIMP-2/SCARB2 protein. |
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| Background | LIMP-2 (lysosomal integral membrane protein type 2)/SCARB2, is a lysosomal membrane glycoprotein and the only endomembrane member of the CD36 scavenger receptor family, which also includes SR-B1 and CD36. Structurally, it contains two transmembrane domains, short cytosolic tails, and a large luminal ectodomain with a hydrophobic tunnel-like cavity that binds and transports cholesterol. Highly expressed in lysosomes, LIMP-2 serves multiple functions: it delivers the lysosomal enzyme β-glucocerebrosidase, acts as a receptor for certain enteroviruses, and mediates lysosomal cholesterol export in parallel with NPC1/2. By shuttling cholesterol (and potentially other lipids) from the lysosomal lumen to the limiting membrane and lipid droplets, LIMP-2 regulates cholesterol homeostasis, LDL receptor expression, and SREBP-2 signaling, linking it to lipid metabolism and lysosomal storage disorders. |
Usage Information
| Application | WB, IP, IF | Dilution |
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| Reactivity | Human, Mouse, Rat | ||||||||
| Source | Rabbit | MW | 54 kDa, 80 kDa | ||||||
| Storage Buffer | PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3 | Storage (from the date of receipt) |
-20°C (avoid freeze-thaw cycles), 2 years | ||||||
References
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