Lapatinib ditosylate monohydrate

Catalog No.S5241 Batch:S524101

Print

Technical Data

Formula

C43H44ClFN4O11S3
Molecular Weight 943.48 CAS No. 388082-78-8
Solubility (25°C)* In vitro DMSO 100 mg/mL (105.99 mM)
Water Insoluble
 
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Lapatinib ditosylate monohydrate (Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate)is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways, used for treatment of solid tumours such as breast and lung cancer.
Targets
ErbB2 [1]
(Cell-free assay)		 EGFR [1]
(Cell-free assay)		 ErbB4 [1]
(Cell-free assay)
9.2 nM 10.8 nM 367 nM

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/12467226/

Selleck's Lapatinib ditosylate monohydrate Has Been Cited by 50 Publications

Effects of lapatinib on cell proliferation and apoptosis in NB4 cells [ Oncology Letters, November 3, 2017, 235-242] PubMed: 29387217
Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation [ PLoS One, May 4, 2020, e0231894] PubMed: 32365111
Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer [ Oncotarget, March 20, 2015, 5678-5694] PubMed: 25691057
Enhanced antitumor activity of lapatinib against triple-negative breast cancer via loading in human serum albumin [ Int J Biol Macromol, 2024, 282(Pt 2):136760] PubMed: 39437943
HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction [ Int J Mol Sci, 2023, 24(7)6228] PubMed: 37047202
Irreversible tyrosine kinase inhibitors induce the endocytosis and downregulation of ErbB2 [ Biochem Biophys Rep, 2023, 34:101436] PubMed: 36824069
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy [ Cancer Discov, 2022, 12(1):204-219] PubMed: 34544753
Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets [ Nat Commun, 2022, 13(1):6481] PubMed: 36309506
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer [ Nat Chem Biol, 2022, 10.1038/s41589-022-00984-x] PubMed: 35273398
Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells [ Cancer Res, 2022, can.21.2908] PubMed: 35792658

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.