KL001

Catalog No.S6304 Batch:S630401

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Technical Data

Formula

C21H22N2O4S
Molecular Weight 398.48 CAS No. 309928-48-1
Solubility (25°C)* In vitro DMSO 80 mg/mL (200.76 mM)
Ethanol 80 mg/mL (200.76 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description KL001 is a stabilizer that specifically interacts with cryptochrome (CRY). KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period.
Targets
CRY [1]
In vitro

Treatment with KL001, which is a stabilizer of CRY1 and CRY2, promotes proliferation, migration, and tubular formation of HUVECs.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Human umbilical vein endothelial cells (HUVECs)

  • Concentrations

    40 μM

  • Incubation Time

    16 h

  • Method

    HUVECs were cultured with 0.1% dimethyl sulfoxide (vehicle group) or 40 μmol/L of KL001 (funakoshi) in EBM‐2 with 0.5% FBS for 16 hours.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.