IPI-3063

Catalog No.S7335 Batch:S733502

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Technical Data

Formula

C25H25N7O2
Molecular Weight 455.51 CAS No. 1425043-73-7
Solubility (25°C)* In vitro DMSO 91 mg/mL (199.77 mM)
Ethanol 2 mg/mL (4.39 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.
Targets
p110δ [1]
(Cell-free assay)
2.5 nM
In vitro IPI-3063 is a p110δ selective compound with an IC50 = 0.1 nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation[1].
In vivo IPI-3063 has good pharmacokinetics in mice[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    purified mouse B cells

  • Concentrations

    0.01, 0.1, 1, 10, 30, 100 nM

  • Incubation Time

    48 h

  • Method

    Purified mouse B cells are incubated for 48 h in either B-cell activating factor (BAFF) or interleukin-4 (IL-4) with various concentrations of IPI-3063 and IPI-443.
Animal Study:

[2]
  • Animal Models

    Brown Norway rats

  • Dosages

    50 mg/kg

  • Administration

    oral administration

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.