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Biological Description
| Specificity | IGF2BP2/IMP-2 Antibody [H6A9] detects endogenous levels of total IGF2BP2/IMP-2 protein. |
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| Background | IGF2BP2, also known as IMP-2, is an RNA-binding protein belonging to the IGF2 mRNA-binding protein family, characterized by two N-terminal RNA recognition motifs (RRMs) and four C-terminal K homology (KH) domains, which are essential for RNA binding, stability, and localization. These domains mediate the formation of stable ribonucleoprotein complexes essential for mRNA transport, storage, and translational regulation, preferentially binding to N6-methyladenosine (m6A)-modified mRNAs. IGF2BP2 'cages' target transcripts by recruiting them to cytoplasmic protein-RNA assemblies (mRNPs), protecting them from degradation and regulating their spatial and temporal translation; it specifically binds to the 5′-UTR of insulin-like growth factor 2 (IGF2) mRNAs and enhances the stability of oncogenic transcripts like MYC by binding to the coding region instability determinant (CRD), a process enhanced by m6A modifications. IGF2BP2 is implicated in cancer progression and metabolic disorders through its regulation of target mRNAs involved in proliferation and metabolism. |
Usage Information
| Application | WB, IHC, IF | Dilution |
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| Reactivity | Mouse, Rat, Human | ||||||||
| Source | Rabbit Monoclonal Antibody | MW | 66 kDa | ||||||
| Storage Buffer | PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3 | Storage (from the date of receipt) |
-20°C (avoid freeze-thaw cycles), 2 years | ||||||
References
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