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Description
| Specificity | IFNAR1 Rabbit Recombinant mAb detects endogenous level of total IFNAR1. |
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| Background | The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. IFNAR1 is the low affinity subunit. Its cytoplasmic domain associates with Tyk2 and Tyk2 is required for membrane expression of IFNAR1. In the absence of Tyk2, a cytoplasmic IFNAR1 motif is phosphorylated, inducing receptor internalization. IFNAR1 then localizes to the perinuclear endosomal compartment and is degraded. IFNAR1 binding to low affinity ligands, such as IFNα subtypes, has been proposed to be the rate limiting step in the ternary complex formation. |
Usage Information
| Application | WB ,ELISA | ||
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| Dilution |
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| Reactivity | Human | ||
| MW (kDa) | 90,130kDa | ||
| Source | Rabbit | ||
| Concentration | 1mg/ml | ||
| Storage buffer | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| Storage (From the date of receipt) |
Store at –20°C. |
References
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Application Data
WB