Iberdomide (CC220)

Catalog No.S8760 Batch:S8760

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Technical Data

Formula

C25H27N3O5
Molecular Weight 449.50 CAS No. 1323403-33-3
Solubility (25°C)* In vitro DMSO 90 mg/mL (200.22 mM)
Ethanol 7 mg/mL (15.57 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. It induces apoptosis with antitumor and immunostimulatory activities.
Targets
cereblon [1]
60 nM
In vitro

Iberdomide (CC-220) is a potent anti-proliferative and pro-apoptotic compound that shows activity in several MM cell line categories. It induces PBMC-mediated killing of all MM cell lines regardless of the level of Cereblon expression and cell autonomous sensitivity. This compound acts through binding of Cereblon, leading to the degradation of the hematopoietic transcription factors Ikaros and Aiolos, followed by disruption of the MM promoting c-Myc/IRF4 axis[2].

In cellular degradation assays, treatment with it results in the loss of Ikaros protein levels with an EC50 of 1 nM. It is similarly potent toward Aiolos, with an EC50 of 0.5 nM[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    DF15 cells

  • Concentrations

    60 nM

  • Incubation Time

    5 h

  • Method

    After treatment with Iberdomide (CC-220) for 5 h, the cells were harvested.
Animal Study:

[3]
  • Animal Models

    Transgenic mice

  • Dosages

    10 mg/kg

  • Administration

    o.g.

References

  • https://pubmed.ncbi.nlm.nih.gov/28425720/
  • http://www.bloodjournal.org/content/128/22/1591?sso-checked=true
  • https://pubmed.ncbi.nlm.nih.gov/34258584/

Selleck's Iberdomide (CC220) Has Been Cited by 13 Publications

A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities [ Cell Rep Med, 2025, S2666-3791(25)00102-8] PubMed: 40147445
Novel Cereblon-Binding Immunomodulators Have Increased Potency Against Gammaherpesvirus- Associated Lymphomas In Vitro [ J Med Virol, 2025, 97(8):e70537] PubMed: 40767544
The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wildtype p53 to Exert the Dominant-Negative Effect [ Cancer Res, 2025, 10.1158/0008-5472.CAN-24-1136] PubMed: 40163352
Role of Rac1 in p53-Related Proliferation and Drug Sensitivity in Multiple Myeloma [ Cancers (Basel), 2025, 17(3)461] PubMed: 39941828
Mapping the IMiD-dependent cereblon interactome using BioID-proximity labelling [ FEBS J, 2024, 10.1111/febs.17196] PubMed: 38975872
Degradome analysis to identify direct protein substrates of small-molecule degraders [ bioRxiv, 2024, 10.1101/2024.01.28.577572] PubMed: none
IMiDs Augment CD3-Bispecific Antibody-Induced CD8+ T-Cell Cytotoxicity and Expansion by Enhancing IL2 Production [ Mol Cancer Ther, 2023, 22(5):659-666] PubMed: 36822576
IMiDs Augment CD3-Bispecific Antibody-Induced CD8+ T-Cell Cytotoxicity and Expansion by Enhancing IL2 Production [ Mol Cancer Ther, 2023, 22(5):659-666] PubMed: 36822576
IMiDs Augment CD3-Bispecific Antibody-Induced CD8+ T-Cell Cytotoxicity and Expansion by Enhancing IL2 Production [ Mol Cancer Ther, 2023, 22(5):659-666] PubMed: 36822576
Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling [ Cell Chem Biol, 2022, S2451-9456(22)00204-5] PubMed: 35732177

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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