|
How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
||
|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. We strive to reply to |
Technical Data
| Formula | C20H20BrN3O2S |
|||
| Molecular Weight | 446.36 | CAS No. | 127243-85-0 | |
| Solubility (25°C)* | In vitro | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Biological Activity
| Description | H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 values of 48 nM and has weak inhibition against PKG, PKC, Casein Kinase, and other kinases. |
|---|
Protocol (from reference)
References
|
Selleck's H-89 Has Been Cited by 10 Publications
| The cAMP-PKA signaling initiates mitosis by phosphorylating Bora [ Nat Commun, 2025, 16(1):7898] | PubMed: 40849432 |
| LncRNA MRF targeting FSHR inhibits the osteogenic differentiation of BMSCs and bone defect repair through the regulation of the cAMP-PKA-CREB signaling pathway [ Stem Cell Res Ther, 2025, 16(1):200] | PubMed: 40264197 |
| Prostaglandin E2 inhibits the differentiation of T regulatory cells by Peroxisome Proliferator-Activated Receptor [ Asian Pacific Journal of Allergy and Immunology, 2025, 214-226] | PubMed: 38877848.0 |
| HDAC7 promotes renal cancer progression by reprogramming branched-chain amino acid metabolism [ Sci Adv, 2025, 11(23):eadt3552] | PubMed: 40465706 |
| The chemosensory function of primary cilia regulates cholangiocyte migration, invasion and tumor growth [ Hepatology, 2019, 1582-1598] | PubMed: 30299561.0 |
| Glutathione S-Transferase Pi Prevents Sepsis-Related High Mobility Group Box-1 Protein Translocation and Release [ Frontiers in Immunology, 2018, 268] | PubMed: 29520271.0 |
| GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis [ Cellular Physiology and Biochemistry, 2017, 1165-1176] | PubMed: 28668964.0 |
| EPAC-RAP1 Axis-mediated Switch in the Response of Primary and Metastatic Melanoma to cyclic AMP [ Molecular Cancer Research, 2017, 1792-1802] | PubMed: 28851815.0 |
| Protein kinase inhibitor H89 enhances the activity of Pseudomonas exotoxin A-based immunotoxins [ Molecular Cancer Therapeutics, 2016, 1053–1062] | PubMed: 26939705.0 |
| Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells [ Endocrinology, 2016, 2173–2181] | PubMed: 26950201.0 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.