GNE-477

Catalog No.S6516 Batch:S651601

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Technical Data

Formula

C21H28N8O3S2

Molecular Weight 504.63 CAS No. 1032754-81-6
Solubility (25°C)* In vitro DMSO 25 mg/mL (49.54 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR.
Targets
PI3Kα [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
4 nM 21 nM(Ki app) 21 nM(Ki app)

Protocol (from reference)

Selleck's GNE-477 has been cited by 1 publication

The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells [ Front Pharmacol, 2021, 12:659511] PubMed: 34381355

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.