Glucose Transporter GLUT2 Rabbit mAb

Catalog No.: F2776

打印

Biological Description

Specificity Glucose Transporter GLUT2 Rabbit mAb detects endogenous levels of total Glut2 protein.
Background Glucose Transporter GLUT2, encoded by the SLC2A2 gene on chromosome 3q26.2, is a low-affinity, high-capacity facilitative glucose transporter belonging to the glucose transporter (GLUT) family. Structurally, it is a membrane glycoprotein with 14 transmembrane domains that mediates bidirectional, passive glucose transport to equilibrate glucose concentrations across membranes. GLUT2 is primarily expressed in the liver, pancreatic β cells, small intestine, kidney, and certain central nervous system regions. Functionally, it plays a pivotal role in glucose homeostasis by enabling glucose uptake for metabolism, sensing blood glucose levels (particularly in β cells and the CNS), mediating intestinal glucose/fructose absorption, hepatic glucose/fructose clearance, and renal glucose reabsorption. It suits for handling postprandial glucose surges, and variations in GLUT2 are linked to metabolic disorders such as type 2 diabetes, Fanconi–Bickel syndrome, and altered sugar preference.

Usage Information

Application WB Dilution
WB
1:1000-1:10000
Reactivity Human
Source Rabbit MW 57 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

References

  • https://pubmed.ncbi.nlm.nih.gov/37358764/
  • https://pubmed.ncbi.nlm.nih.gov/32591905/

Application Data