Gabexate Mesylate

Catalog No.S2101 Batch:S210101

Print

Technical Data

Formula

C16H23N3O4.CH4O3S
Molecular Weight 417.48 CAS No. 56974-61-9
Solubility (25°C)* In vitro DMSO 83 mg/mL (198.81 mM)
Ethanol 83 mg/mL (198.81 mM)
Water 12 mg/mL (28.74 mM)
In vivo (Add solvents to the product individually and in order)
Clear solution
saline
12.000mg/ml Taking the 1 mL working solution as an example, add 12 mg of this product to 1 ml of physiological saline (0.9% NaCL solution), mix evenly to make it clear, The mixed solution should be used immediately for optimal results.
Homogeneous suspension
CMC-NA
≥5mg/ml Homogeneous suspension for Oral and Intraperitoneal Injection. Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.
Targets
serine protease [1]
0.19 μM

Protocol (from reference)

Customer Product Validation

Data from [ , , Medical Oncology, 2016, 33:53. ]

Selleck's Gabexate Mesylate has been cited by 6 publications

Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862] PubMed: 39319271
Discovery of diminazene as a dual inhibitor of SARS-CoV-2 human host proteases TMPRSS2 and furin using cell-based assays [ Curr Res Chem Biol, 2022, 2:100023] PubMed: 35815069
LSD1 Activates PI3K/AKT Signaling Through Regulating p85 Expression in Prostate Cancer Cells. [ Front Oncol, 2019, 0.87569444444] PubMed: 31428587
Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis [ J Biol Chem, 2018, 293(34):13112-13124] PubMed: 29970616
Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity. [ Invest Ophthalmol Vis Sci, 2016, 57(14):6461-6473] PubMed: 27893888
Inhibition of glioblastoma cell proliferation, migration and invasion by the proteasome antagonist carfilzomib. [Areeb Z, et al. Med Oncol, 2016, 33(5):53] PubMed: 27098175

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.