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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C31H37N7O |
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| Molecular Weight | 523.67 | CAS No. | 2901806-51-5 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | G-6599 is a potent monovalent degrader of SMARCA2/SMARCA4 that covalently binds a cysteine on E3 ligase FBXO22, forming a ternary complex for ubiquitin-proteasome degradation. It exhibits potential research applications in androgen-dependent prostate cancer and SMARCA4-mutant non-small cell lung cancer. |
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Protocol (from reference)
References
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