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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C22H29FN4O2 |
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| Molecular Weight | 400.49 | CAS No. | 2411748-50-8 | ||||
| Solubility (25°C)* | In vitro | DMSO | 40 mg/mL (99.87 mM) | ||||
| Ethanol | 10 mg/mL (24.96 mM) | ||||||
| Water | Insoluble | ||||||
| In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2. | ||
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Protocol (from reference)
References
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Selleck's EZM0414 Has Been Cited by 2 Publications
| IRF1 governs the expression of SMARCC1 via the GCN5-SETD2 axis and actively engages in the advancement of osteoarthritis [ Journal of Orthopaedic Translation, March 28, 2024, 211-225] | PubMed: 38586591 |
| CDK12 Deficiency Induces BRD4S to Promote Cancer Metastasis by Enhancing Phase Separation and Chromatin Engagement [ Cancer Research, March 02, 2026, 1180-1193] | PubMed: 41289556 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.