Eucalyptol

Catalog No.S3761 Batch:S376102

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Technical Data

Formula

C10H18O
Molecular Weight 154.25 CAS No. 470-82-6
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
In vitro

In a concentration-dependent manner, 1,8-Cineol (Eucalyptol) reduces LPS-induced Egr-1 expression in nuclei and in whole cell of THP-1 cells, but shows no effect on NF-κB expression. 1,8-Cineol significantly inhibits cytokine production in human unselected lymphocytes of TNF-α, IL-1β, IL-4, IL-5, and in lipopolysaccharide (LPS)-stimulated monocytes of TNF-α, IL-1β, IL-6, and IL-8[1]. 1,8-Cineol significantly stimulates the transactivation of liver X receptor modulator LXR-α and LXR-β. The mRNA and protein expression of LXRs and their target genes, including ABCA1 and ABCG1, are significantly increased in macrophages stimulated with cineole. This leads to the subsequent removal of cholesterol from the cells[2].
In vivo

In rats, it depresses myocardial contractility in a concentration-dependent way while increasing extracellular Ca2+ concentration. i.v. treatment of both anesthetized and conscious rats with 1,8-cineole lowers blood pressure, probably through an active vascular relaxation rather than withdrawal of sympathetic tone. 1,8-Cineole is also found to relax rat and guinea-pig (nonsensitized and ovalbumin-sensitized) airway smooth muscle by a nonspecific mechanism[2].
Density 0.926 g/mL

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    THP-1 cells

  • Concentrations

    1, 10, and 100 mg/L

  • Incubation Time

    30 min

  • Method

    The THP-1 cells are incubated with serial doses of 1,8-cineol (1, 10, and 100 mg/L, 30 min) before being stimulated with LPS (1 mg/L, 30 min). The localization of Egr-1 in the THP-1 cells is detected by immunofluorescence and a laser scanning confocal microscope. The expression of Egr-1 in the nuclei and whole cell, and NF-κB in the nuclei, are measured by Western blot analysis.
Animal Study:

[1]
  • Animal Models

    Male Swiss mice, Wistar rats

  • Dosages

    100-400 mg/kg

  • Administration

    oral

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.