|CAS No.||481-29-8||Synonyms||3β-androsterone, EpiA|
|Solubility (25°C) *||In vitro||Ethanol||58 mg/mL (199.69 mM)|
|DMSO||29 mg/mL warmed with 50ºC water bath (99.84 mM)|
|In vivo（should be freshly prepared each time）|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Description||Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.|
|In vitro||Epiandrosterone is a natural metabolite of dehydroepiandrosterone (DHEA) via the 5α-reductaseenzyme. Epiandrosterone is formed in peripheral tissues, from which it is released into the circulation and is ultimately excreted in the urine. Epiandrosterone is only a weak androgen, but it is widely recognized to inhibit the pentose phosphate pathway (PPP) and to decrease intracellular NADPH levels.  Epiandrosterone attenuates NO-evoked relaxation of pulmonary artery , although it inhibits angiotensin II- and hypoxia-induced vasoconstriction in isolated lungs and relaxes isolated pulmonary arteries pre-constricted with KCl. |
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