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Epiandrosterone

Catalog No.S2832

Technical Data

Molecular Weight 290.44 Storage powder
in solvent
Formula

C19H30O2

CAS No. 481-29-8 Synonyms 3β-androsterone, EpiA
Chemical Name 3β-Hydroxy-5α-androstane-17-one
Solubility (25°C) * In vitro Ethanol 58 mg/mL (199.69 mM)
DMSO 29 mg/mL warmed with 50ºC water bath (99.84 mM)
Water Insoluble
In vivo(should be freshly prepared each time)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Biological Activity

Description Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.
Targets
AR [1] ER [1]
In vitro Epiandrosterone is a natural metabolite of dehydroepiandrosterone (DHEA) via the 5α-reductaseenzyme. Epiandrosterone is formed in peripheral tissues, from which it is released into the circulation and is ultimately excreted in the urine. Epiandrosterone is only a weak androgen, but it is widely recognized to inhibit the pentose phosphate pathway (PPP) and to decrease intracellular NADPH levels. [1] Epiandrosterone attenuates NO-evoked relaxation of pulmonary artery [2], although it inhibits angiotensin II- and hypoxia-induced vasoconstriction in isolated lungs and relaxes isolated pulmonary arteries pre-constricted with KCl. [3]
In vivo
FeaturesS2832  
 

References:

PLEASE KEEP THE PRODUCT UNDER -20°C FOR LONG-TERM STORAGE.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.

Chemical Structure

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