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Biological Description
| Specificity | Elav-type RNA-binding protein ETR3 Antibody [M8J19] detects endogenous levels of total Elav-type RNA-binding protein ETR3 protein. |
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| Background | Elav-type RNA-binding protein ETR-3 (also known as BRUNOL3, NAPOR, or CUGBP2) is a member of the CELF (CUG-BP and ETR-3-like factor) family of RNA-binding proteins that regulate post-transcriptional gene expression. Structurally, ETR-3 contains three RNA recognition motifs (RRMs)—two near the N-terminus and one at the C-terminus—separated by a divergent central domain (160–230 amino acids) that confers splicing activation potential. ETR-3 is highly expressed in muscle, heart, and brain tissues, where it plays crucial roles in alternative splicing, RNA editing, translation, and mRNA stability. It binds preferentially to UG-rich sequences (UG repeats and UGUU motifs) within pre-mRNAs, regulating exon inclusion or skipping. Through this RNA-binding activity, ETR-3 influences the expression of key genes such as CFTR and MTMR1 and contributes to developmental splicing programs and neuromuscular functions. Dysregulation of ETR-3 and other CELF proteins has been implicated in myotonic dystrophy, where aberrant splicing patterns arise from disrupted CELF and MBNL protein activity. |
Usage Information
| Application | WB, IP, IHC, IF, FCM | Dilution |
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| Reactivity | Human, Mouse, Rat | ||||||||||||
| Source | Rabbit Monoclonal Antibody | MW | 54 kDa | ||||||||||
| Storage Buffer | PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3 | Storage (from the date of receipt) |
-20°C (avoid freeze-thaw cycles), 2 years | ||||||||||
References
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