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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C51H64N12O12S2 |
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| Molecular Weight | 1101.26 | CAS No. | 512-64-1 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Echinomycin (Quinomycin A;NSC-13502) is a potent, cell‑permeable inhibitor of HIF‑1–mediated gene transcription that bis‑intercalates into DNA in a sequence‑specific manner, thereby blocking HIF‑1α/β binding to hypoxia‑responsive elements and reversibly inhibiting hypoxia‑induced HIF‑1 transcriptional activity in U251‑HRE cells with an EC50 of approximately 1.2 nM. |
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Protocol (from reference)
References
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