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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C70H91F3N6O16S | |||
| Molecular Weight | 1361.56 | CAS No. | 2624313-15-9 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | dTAGV-1 TFA is a degrader of FKBP12F36V-tagged proteins that functions as a PROTAC. It mediates the degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand ; Black: Linker ; Blue: VHL Ligand ; VHL Ligand+Linker (A)) |
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| In vivo | dTAGV-1 (35 mg/kg; i.p; 3 days) TFA induces degradation of FKBP12F36V-Nluc in mice. Pharmacokinetic Analysis in Mice (non-salt form) |
Protocol (from reference)
References
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