Doxorubicin

Catalog No.E2516 Batch:E251603

Print

Technical Data

Formula

C27H29NO11
Molecular Weight 543.52 CAS No. 23214-92-8
Solubility (25°C)* In vitro DMSO 100 mg/mL (183.98 mM)
Water 100 mg/mL (183.98 mM)
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis.
Targets
topoisomerase I [3]
(in assay of DNA Topo I activity)		 topoisomerase II [1]
(in decatenation assay for topoisomerase II activity)
0.8 μM 2.67 μM

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/17194596/
  • https://pubmed.ncbi.nlm.nih.gov/19377506/
  • https://pubmed.ncbi.nlm.nih.gov/1318169/

Selleck's Doxorubicin Has Been Cited by 177 Publications

GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM) [ Cell Death Differ, 2026, 10.1038/s41418-026-01679-9] PubMed: 41787053
FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis [ Int J Biol Sci, 2026, 22(4):1793-1806] PubMed: 41694578
Preclinical evaluation of progesterone combined with EDP-M scheme in 2D and 3D models of adrenocortical carcinoma [ Biomed Pharmacother, 2026, 196:119090] PubMed: 41671730
Simultaneous chromatographic quantification of upadacitinib, nilotinib, and tryptophan decoding myeloid leukemia and liver cancer integrated with ELISA and Flow cytometry [ J Chromatogr B Analyt Technol Biomed Life Sci, 2026, 1270:124891] PubMed: 41389544
SenCat: Cataloging human cell senescence through multiomic profiling of multiple senescent primary cell types [ bioRxiv, 2026, 2026.02.05.703986] PubMed: 41867812
BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses [ bioRxiv, 2026, 2026.03.19.712964] PubMed: 41890073
CD36-mediated endocytosis of proteolysis-targeting chimeras [ Cell, 2025, S0092-8674(25)00386-1] PubMed: 40250420
A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy [ Cell Stem Cell, 2025, S1934-5909(25)00265-6] PubMed: 40812300
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells [ Nat Cell Biol, 2025, 27(6):1021-1034] PubMed: 40419795
The cAMP-PKA signaling initiates mitosis by phosphorylating Bora [ Nat Commun, 2025, 16(1):7898] PubMed: 40849432

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.