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Technical Data
| Formula | C27H29NO11 |
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| Molecular Weight | 543.52 | CAS No. | 23214-92-8 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (183.98 mM) | |
| Water | 100 mg/mL (183.98 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM. | ||||
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Protocol (from reference)
References
Selleck's Doxorubicin has been cited by 153 publications
| Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies [ Adv Sci (Weinh), 2025, 12(1):e2404109] | PubMed: 39520088 |
| Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation [ Adv Sci (Weinh), 2025, 12(10):e2413174] | PubMed: 39813169 |
| Smad1 Promotes Tumorigenicity and Chemoresistance of Glioblastoma by Sequestering p300 From p53 [ Adv Sci (Weinh), 2025, 12(4):e2402258] | PubMed: 39629919 |
| Construction of human pluripotent stem cell-derived testicular organoids and their use as humanized testis models for evaluating the effects of semaglutide [ Theranostics, 2025, 15(6):2597-2623] | PubMed: 39990223 |
| Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells [ Cell Death Discov, 2025, 11(1):133] | PubMed: 40175326 |
| The Role of Elacridar, a P-gp Inhibitor, in the Re-Sensitization of PAC-Resistant Ovarian Cancer Cell Lines to Cytotoxic Drugs in 2D and 3D Cell Culture Models [ Int J Mol Sci, 2025, 26(3)1124] | PubMed: 39940891 |
| Daurisoline Inhibits Progression of Triple-Negative Breast Cancer by Regulating the γ-Secretase/Notch Axis [ Biomol Ther (Seoul), 2025, 33(2):331-343] | PubMed: 39933901 |
| Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity [ BMC Immunol, 2025, 26(1):4] | PubMed: 39844069 |
| Knockdown of EBP1 promotes doxorubicin-induced apoptosis in renal clear cell carcinoma cells through activation of the p38/HIF-1α pathway [ Oncol Lett, 2025, 29(4):172] | PubMed: 39968014 |
| Eribulin Induction of Immunogenic Cell Death (ICD): Comparison With Other Cytotoxic Agents and Temporal Relationship of ICD Biomarkers [ Anticancer Res, 2025, 45(1):39-53] | PubMed: 39740820 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.