Dicoumarol

Catalog No.S4299 Batch:S429903

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Technical Data

Formula

C19H12O6

Molecular Weight 336.29 CAS No. 66-76-2
Solubility (25°C)* In vitro DMSO 3 mg/mL (8.92 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K.
Targets
NQO1 [1]

Protocol (from reference)

Selleck's Dicoumarol has been cited by 10 publications

Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice [ Acta Pharmacol Sin, 2023, 1-13.] PubMed: 36697978
Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology [ Anal Chem, 2023, 95(13):5661-5670] PubMed: 36952386
Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells [ Toxicol Lett, 2023, 378:39-50] PubMed: 36863539
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors Necrostatin-1 (Nec-1) and 7-Cl-O-Nec-1 (Nec-1s) are potent inhibitors of NAD(P)H: Quinone oxidoreductase 1 (NQO1) [ Free Radic Biol Med, 2021, 173:64-69] PubMed: 34252539
A novel strategy for glioblastoma treatment by induction of noptosis, an NQO1-dependent necrosis [ Free Radic Biol Med, 2021, 166:104-115] PubMed: 33600944
2-Methoxy-6-acetyl-7-methyljuglone (MAM) Induced Programmed Necrosis in Glioblastoma by Targeting NAD(P)H: Quinone Oxidoreductase 1 (NQO1) [ Free Radic Biol Med, 2020, 28;152:336-347] PubMed: 32234332
NQO1 Is a Determinant for Cellular Sensitivity to Anti-Tumor Agent Napabucasin [ Am J Cancer Res, 2020, 1;10(5):1442-1454] PubMed: 32509390
Inhibition of pyruvate dehydrogenase kinase‑1 by dicoumarol enhances the sensitivity of hepatocellular carcinoma cells to oxaliplatin via metabolic reprogramming [ Int J Oncol, 2020, 57(3):733-742] PubMed: 32705170
Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death. [ Clin Cancer Res, 2019, 25(23):7162-7174] PubMed: 31527169
Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells. [ PLoS One, 2017, 12(6):e0179672] PubMed: 28617852

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.