Demethylnobiletin

Catalog No.S9421 Batch:S942102

Technical Data

Formula

C₂₀H₂₀O₈

Molecular Weight

388.37

CAS No.

2174-59-6

Solubility (25°C)*

In vitro

DMSO

32 mg/mL (82.39 mM)

In vivo (Add solvents to the product individually and in order)

Clear solution

5%DMSO 1 Corn oil

1.6mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 32 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers.5-Demethylnobiletin is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. 5-Demethylnobiletin has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.

Description

Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers.5-Demethylnobiletin is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. 5-Demethylnobiletin has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.

Protocol (from reference)

Selleck's Demethylnobiletin has been cited by 1 publication

5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1/2/AKT/STAT3 signaling pathways in glioblastoma cells [ Front Oncol, 2023, 13:1143664]	PubMed: 37139163

5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1/2/AKT/STAT3 signaling pathways in glioblastoma cells [ Front Oncol, 2023, 13:1143664]

PubMed: 37139163

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.