δ-Tocotrienol

Catalog No.E7357 Batch:E735701

Technical Data

Formula

C₂₇H₄₀O₂

Molecular Weight

396.61

CAS No.

25612-59-3

Solubility (25°C)*

In vitro

DMSO

79 mg/mL (199.18 mM)

Ethanol

79 mg/mL (199.18 mM)

Water

Insoluble

In vivo (Add solvents to the product individually and in order)

Homogeneous suspension	CMC-NA	≥5mg/ml	Homogeneous suspension for Oral and Intraperitoneal Injection. Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	2.000mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	0.350mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 7 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	δ-Tocotrienol is a form of vitamin E that disrupts PD-L1 glycosylation by inhibiting the TCF4-STT3 pathway, leading to lower PD-L1 expression and reduced exosomal release. This reduction in PD-L1 impairs the PD-L1/PD-1 interaction, thereby reversing immune suppression. It also inhibits prostate cancer development by reducing cell proliferation, promoting apoptosis, and blocking angiogenesis in Ptenp−/− mice.

Description

δ-Tocotrienol is a form of vitamin E that disrupts PD-L1 glycosylation by inhibiting the TCF4-STT3 pathway, leading to lower PD-L1 expression and reduced exosomal release. This reduction in PD-L1 impairs the PD-L1/PD-1 interaction, thereby reversing immune suppression. It also inhibits prostate cancer development by reducing cell proliferation, promoting apoptosis, and blocking angiogenesis in Ptenp−/− mice.

Protocol (from reference)

References

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.