Dantrolene

Catalog No.E4902 Batch:E490201

Technical Data

Formula

C₁₄H₁₀N₄O₅

Molecular Weight

314.25

CAS No.

7261-97-4

Solubility (25°C)*

In vitro

DMSO

21 mg/mL (66.82 mM)

Water

Insoluble

Ethanol

Insoluble

In vivo (Add solvents to the product individually and in order)

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.500mg/ml (1.59mM)	Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.100mg/ml (0.32mM)	Taking the 1 mL working solution as an example, add 50 μL of 2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Dantrolene is an antagonist of ryanodine receptor (RYR) and a postsynaptic skeletal muscle relaxant that reduces calcium release from the sarcoplasmic reticulum (SR), leading to a dose-dependent decrease in myoplasmic free calcium levels. It is used to treat and control the accelerated hypermetabolism of skeletal muscle that leads to a malignant hyperthermia crisis.

Protocol (from reference)

References

https://pubmed.ncbi.nlm.nih.gov/20861418/
https://pubmed.ncbi.nlm.nih.gov/10439768/

Selleck's Dantrolene Has Been Cited by 8 Publications

Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication [ PLoS Pathogens, March 27, 2023, e1011295]
Ergothioneine Stimulates Ca2+-Mediated Brain-Derived Neurotrophic Factor Expression in NE-4C Nerve Cells [ ACS Omega, February 16, 2025, nan]
Activation of Piezo 1 in the Pathogenesis of Glaucoma [ Neuropharmacology and Therapy, 2025, 13-25]	PubMed: nan
Activation of Piezo 1 in the Pathogenesis of Glaucoma [ Neuropharmacology and Therapy, 2025, 13-25]
NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia [ Nat Cell Biol, 2024, ]	PubMed: 39506072
African swine fever virus modulates the endoplasmic reticulum stress-ATF6-calcium axis to facilitate viral replication [ Emerging Microbes & Infections, 2024, 2399945]	PubMed: 39230190
Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication [ PLOS Pathogens, 2023, e1011295]	PubMed: nan
Drug library screen identifies inhibitors of toxic astrogliosis [ Multiple Sclerosis and Related Disorders, 2022, 103499]	PubMed: 35030368

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.