Cytosporone B

Catalog No.S6674 Batch:S667402

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Technical Data

Formula

C18H26O5
Molecular Weight 322.40 CAS No. 321661-62-5
Solubility (25°C)* In vitro DMSO 64 mg/mL (198.51 mM)
Ethanol 64 mg/mL (198.51 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Cytosporone B is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278nM.
Targets
Nur77 [1]
(Cell-free assay)
0.278 nM(EC50)
In vitro

Cytosporone B effectively decreases the TGF-β1-dependent elevated expression of fibrotic markers in vitro.[2]
In vivo

Cytosporone B, an NR4A1 agonist, effectively suppresses fibrogenesis in mouse endometriotic tissue.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Human ectopic endometrial stromal cells (EESCs), normal endometrial stromal cells (NESCs)

  • Concentrations

    1 μM

  • Incubation Time

    24 h

  • Method

    After being incubated with Csn-B (1 μmol), siRNA, and TGF-β1 for 24 h, total RNA from cells is extracted with TRIzol reagent for PCR analysis. Proteins from cells Are extracted for Western blot analysis.

Selleck's Cytosporone B has been cited by 5 publications

Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation [ Mol Med, 2023, 29(1):63] PubMed: 37161357
FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression [ Signal Transduct Target Ther, 2021, 6(1):133] PubMed: 33762571
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy [ J Pineal Res, 2018, 64(1)] PubMed: 28981157
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy [ J Pineal Res, 2018, 64(1)] PubMed: 28981157
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis. [ Cell Physiol Biochem, 2018, 46(3):1078-1090] PubMed: 29669342

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.