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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C29H22N2O2 |
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| Molecular Weight | 430.5 | CAS No. | ||
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | CLM296 is a potent and selective ALDH1A3 inhibitor with an IC50 of 2 nM in TNBC cells and no detectable off-target activity against the closely related ALDH1A1 isoform. It selectively suppresses ALDH1A3-driven transcriptional programs and reduces ALDH1A3-mediated cellular invasion in vitro. ALDH1A3 also inhibits dependent tumor growth and lung metastasis in TNBC xenograft models. |
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Protocol (from reference)
References
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