Cerulenin

Catalog No.S8937 Batch:S893702

Technical Data

Formula	C12H17NO3
Molecular Weight	223.27	CAS No.	17397-89-6
Solubility (25°C)*	In vitro	DMSO	45 mg/mL (201.54 mM)
		Ethanol	45 mg/mL (201.54 mM)
		Water	2 mg/mL (8.95 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Cerulenin is a natural epoxide compound produced by the fungus Cephalosporium caeruleus that inhibits fatty acid synthase (FASN). This compound reduces topoisomerase I catalytic activity and enhances SN-38-induced apoptosis. Cerulenin exhibits both antifungal and antitumor properties.
In vivo	Cerulenin treatment of ob/ob mice has obvious effects on body weight. With 2 days of treatment, body weight in treated mice is decreased compared to a 5.7% weight gain in the controls. With prolonged (7 days) treatment, no body weight loss is observed, but body weight gain is slowed. In all groups, 60 mg/kg of Cerulenin is more effective than 30 mg/kg in inhibiting weight gain. If given daily or every other day, ATP content are increased 58.1% and 61.5% respectively by 7-day treatment of 60 mg/kg Cerulenin. Significant ATP elevation is also observed with only 2 days of treatment with 60 mg/kg Cerulenin. In contrast, 30 mg/kg Cerulenin, given either 2 or 7 days, does not show any significant effect on cellular ATP content.

Description

Cerulenin is a natural epoxide compound produced by the fungus Cephalosporium caeruleus that inhibits fatty acid synthase (FASN). This compound reduces topoisomerase I catalytic activity and enhances SN-38-induced apoptosis. Cerulenin exhibits both antifungal and antitumor properties.

In vivo

Cerulenin treatment of ob/ob mice has obvious effects on body weight. With 2 days of treatment, body weight in treated mice is decreased compared to a 5.7% weight gain in the controls. With prolonged (7 days) treatment, no body weight loss is observed, but body weight gain is slowed. In all groups, 60 mg/kg of Cerulenin is more effective than 30 mg/kg in inhibiting weight gain. If given daily or every other day, ATP content are increased 58.1% and 61.5% respectively by 7-day treatment of 60 mg/kg Cerulenin. Significant ATP elevation is also observed with only 2 days of treatment with 60 mg/kg Cerulenin. In contrast, 30 mg/kg Cerulenin, given either 2 or 7 days, does not show any significant effect on cellular ATP content.

Protocol (from reference)

References

https://www.ncbi.nlm.nih.gov/24044691
https://www.ncbi.nlm.nih.gov/23170972
https://www.ncbi.nlm.nih.gov/24086674

https://pubmed.ncbi.nlm.nih.gov/23108760/

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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