Cefuroxime sodium

Catalog No.S4620 Batch:S462001

Technical Data

Formula	C₁₆H₁₆N₄O₈S.Na
Molecular Weight	446.37	CAS No.	56238-63-2
Solubility (25°C)*	In vitro	DMSO	89 mg/mL (199.38 mM)
		Water	89 mg/mL (199.38 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Cefuroxime Sodium is a cephalosporin effective against gram-positive and gram-negative bacteria with resistance to β-lactamase.
In vivo	The intravenous LD50 of cefuroxime sodium for mice is 10.4 g/kg. The maximum dosage administered in other acute toxicity tests is well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). However, when cefuroxime sodium is administered subcutaneously (s.c.) or intramuscularly (i.m.) for 3 months to rats (100, 300 or 900 mg/kg/day) followed by a recovery period, and also for 6 months to rats and dogs (50, 150 or 450 mg/kg/day) and for 1 month to monkeys (150 or 450 mg/kg/day), there are no serious toxic effects in all tests. In rats large doses cause some increase in urine volume and electrolyte excretion, and slightly aggravates an age related nephropathy. Administration to rats intravenously (i.v.) for 1 month of up to 400 mg/kg/day has no toxic effects. In reproduction studies on mice and rabbits there are no adverse effects on fertility, organogenesis or the rearing of young^[1].

Description

Cefuroxime Sodium is a cephalosporin effective against gram-positive and gram-negative bacteria with resistance to β-lactamase.

In vivo

The intravenous LD50 of cefuroxime sodium for mice is 10.4 g/kg. The maximum dosage administered in other acute toxicity tests is well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). However, when cefuroxime sodium is administered subcutaneously (s.c.) or intramuscularly (i.m.) for 3 months to rats (100, 300 or 900 mg/kg/day) followed by a recovery period, and also for 6 months to rats and dogs (50, 150 or 450 mg/kg/day) and for 1 month to monkeys (150 or 450 mg/kg/day), there are no serious toxic effects in all tests. In rats large doses cause some increase in urine volume and electrolyte excretion, and slightly aggravates an age related nephropathy. Administration to rats intravenously (i.v.) for 1 month of up to 400 mg/kg/day has no toxic effects. In reproduction studies on mice and rabbits there are no adverse effects on fertility, organogenesis or the rearing of young^[1].

Protocol (from reference)

References

[1] Capel-Edwards K, et al. Toxicology. 1979, 13(1):1-5.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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