|
How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
||
|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. We strive to reply to |
Technical Data
| Formula | C48H52F2O11S2 |
||||||
| Molecular Weight | 907.05 | CAS No. | 928672-86-0 | ||||
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (110.24 mM) | ||||
| Ethanol | 100 mg/mL (110.24 mM) | ||||||
| Water | Insoluble | ||||||
| In vivo (Add solvents to the product individually and in order) |
|
||||||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
|||||||
Preparing Stock Solutions
Biological Activity
| Description | Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. | ||||
|---|---|---|---|---|---|
| Targets |
|
Protocol (from reference)
References
|
Selleck's Canagliflozin hemihydrate Has Been Cited by 12 Publications
| The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels [ Diabetes, July 05, 2016, 2784-2794] | |
| Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling [ Journal of Clinical Investigation, January 03, 2023, e154754] | PubMed: 36594471 |
| Canagliflozin Inhibits Human Endothelial Cell Inflammation through the Induction of Heme Oxygenase-1 [ International Journal of Molecular Sciences, 2022 Aug 7, 8777] | PubMed: 35955910 |
| CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome [ Front Pharmacol, 2022, 13:848310] | PubMed: 35370759 |
| Canagliflozin promotes osteoblastic MC3T3-E1 differentiation via AMPK/RUNX2 and improves bone microarchitecture in type 2 diabetic mice [ Frontiers in Endocrinology, 2022, 1081039] | PubMed: 36589840 |
| Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy [ Yonsei Med J, 2022, 63(7):619-631] | PubMed: 35748073 |
| The Sodium-Glucose Cotransporter-2 Inhibitor Canagliflozin Alleviates Endothelial Dysfunction Following In Vitro Vascular Ischemia/Reperfusion Injury in Rats [ International Journal of Molecular Sciences, 2021, 7774] | PubMed: 34360539 |
| Canagliflozin inhibits vascular smooth muscle cell proliferation and migration: Role of heme oxygenase-1 [ Redox Biology, 2020 May, 101527] | PubMed: 32278282 |
| Mechanisms of SGLT2 (Sodium-Glucose Transporter Type 2) Inhibition-Induced Relaxation in Arteries From Human Visceral Adipose Tissue [ Hypertension, 2020, 729-738] | PubMed: 33356396 |
| Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation [ Frontiers in Pharmacology, 2019 Apr 16, 362] | PubMed: 31057401 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.