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Technical Data
| Formula | C26H32O11 |
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| Molecular Weight | 520.53 | CAS No. | 14907-98-3 | ||||||||
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (192.11 mM) | ||||||||
| Water | Insoluble | ||||||||||
| Ethanol | Insoluble | ||||||||||
| In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor. | |
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| In vitro | Brusatol provokes a rapid and transient depletion of Nrf2 protein, through a posttranscriptional mechanism, in mouse Hepa-1c1c7 hepatoma cells and freshly isolated primary human hepatocytes [1]. |
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| In vivo | Brusatol inhibits Nrf2 signaling, reduces tumor burden, and ameliorates chemoresistance in both in vitro and in vivo cancer models[1]. |
Protocol (from reference)
Selleck's Brusatol has been cited by 14 publications
| Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment [ Iran J Immunol, 2024, 21(1)] | PubMed: 38314669 |
| DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination [ Adv Sci (Weinh), 2023, 10(14):e2204438] | PubMed: 36965071 |
| Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke [ J Pharm Anal, 2023, 13(2):156-169] | PubMed: 36908855 |
| Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer [ Cancers (Basel), 2023, 15(12)3089] | PubMed: 37370701 |
| Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway [ World J Stem Cells, 2023, 15(11):1017-1034] | PubMed: 38058959 |
| Targeting SELPLG/P-selectin glycoprotein ligand 1 in preclinical ARDS: Genetic and epigenetic regulation of the SELPLG promoter [ Pulm Circ, 2023, 13(1):e12206] | PubMed: 36873461 |
| MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway [ Redox Biol, 2022, 53:102325] | PubMed: 35525026 |
| KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H 2S axis and contributes to pancreatic cancer growth [ Acta Biochim Biophys Sin (Shanghai), 2022, 54(11):1731-1739] | PubMed: 36514219 |
| Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway [ Exp Ther Med, 2022, 23(4):303] | PubMed: 35340877 |
| Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair [ Nucleic Acids Res, 2021, gkab871] | PubMed: 34606602 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.