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Technical Data
| Formula | C21H21FN4O3 |
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| Molecular Weight | 396.41 | CAS No. | ||
| Solubility (25°C)* | In vitro | DMSO | 26 mg/mL (65.58 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | BMS-986449 is a CELMoD molecular glue compound that functions as an IKZF2/IKZF4 degrader. It specifically mediates the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. Through CRBN (Cereblon)-mediated ubiquitination, BMS-986449 induces proteasomal degradation of these targets, leading to Treg cell reprogramming and enhanced antitumor immune responses. This agent shows potential for investigation in advanced solid malignancies. | |||||
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| Density | g/mL | |||||
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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