β Amyloid 1-42 Rabbit mAb

Catalog No.: F3375

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Biological Description

Specificity β Amyloid 1-42 Rabbit mAb detects endogenous levels of total β Amyloid 1-42 protein.
Background Amyloid β 1-42 (Aβ42) is a 42–amino acid peptide generated from the amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase in neurons. Structurally, Aβ42 is highly hydrophobic at its C-terminus, promoting a conformational shift from α-helix to β-sheet that facilitates aggregation into soluble oligomers, protofibrils, and insoluble amyloid fibrils. Aβ42 is expressed primarily in the brain, especially in the neocortex, and is more aggregation-prone and neurotoxic than the shorter Aβ40 form. Functionally, pathological accumulation of Aβ42—particularly as soluble oligomers—is strongly implicated in Alzheimer’s disease pathogenesis by disrupting synaptic signaling, impairing memory, and contributing to plaque formation.

Usage Information

Application IHC Dilution
IHC
1:1000
Reactivity Mouse, Rat, Human
Source Rabbit MW
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

Application Data