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Biological Description
| Specificity | β Amyloid 1-40 Rabbit mAb detects the Aβ-40 isoform of the β-amyloid peptides. |
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| Background | β-Amyloid 1-40 (Aβ40) is a 40-amino-acid peptide generated from the amyloid precursor protein (APP), a type I transmembrane glycoprotein highly expressed in neurons, through sequential cleavage by β-secretase and γ-secretase in the amyloidogenic pathway. Structurally, Aβ40 is intrinsically unstructured in solution but can adopt α-helical or β-sheet conformations depending on the environment; its hydrophobic C-terminal region is crucial for aggregation, while the N-terminal segment is more polar and solvent-exposed. In the healthy brain, APP and its cleavage products, including Aβ40, are involved in synaptic function, neuronal development, and signaling, but excessive Aβ40—especially when misfolded into β-sheet–rich oligomers and fibrils—contributes to amyloid plaque formation, neurotoxicity, and the pathogenesis of Alzheimer’s disease. |
Usage Information
| Application | WB, IHC, I-ELISA | Dilution |
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| Reactivity | Human | ||||||
| Source | Rabbit | MW | 86 kDa | ||||
| Storage Buffer | PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3 | Storage (from the date of receipt) |
-20°C (avoid freeze-thaw cycles), 2 years | ||||
References
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