Bentamapimod (AS602801)

Catalog No.S8867 Batch:S886701

Technical Data

Formula

C₂₅H₂₃N₅O₂S

Molecular Weight

457.55

CAS No.

848344-36-5

Solubility (25°C)*

In vitro

DMSO

24 mg/mL (52.45 mM)

Water

Insoluble

Ethanol

Insoluble

In vivo (Add solvents to the product individually and in order)

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.4mg/ml (0.87mM)	Taking the 1 mL working solution as an example, add 50 μL of 8 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.1mg/ml (0.22mM)	Taking the 1 mL working solution as an example, add 50 μL of 2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

An orally active JNK inhibitor, Bentamapimod (AS602801) exhibits IC50 values of 80 nM, 90 nM and 230 nM for JNK1, JNK2 and JNK3 respectively.

Targets

JNK1 ^[1] (Cell-free assay)	JNK2 ^[1] (Cell-free assay)	JNK3 ^[1] (Cell-free assay)
80 nM	90 nM	230 nM

In vitro

Bentamapimod (AS602801) exhibits cytotoxicity in vitro against both serum-cultured non-stem cancer cells and cancer stem cells derived from human pancreatic cancer, non-small cell lung cancer, ovarian cancer and glioblastoma at concentrations that do not decrease the viability of normal human fibroblasts. It also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells surviving treatment with this compound^[2].

In vivo

Systemic administration of Bentamapimod (AS602801) at a dose and schedule that did not adversely affect the health of the tumor-bearing mice reduced cancer stem cells in established xenograft tumors^[2].

Protocol (from reference)

References

https://pubmed.ncbi.nlm.nih.gov/29267206/
https://pubmed.ncbi.nlm.nih.gov/27027242/

Selleck's Bentamapimod (AS602801) Has Been Cited by 3 Publications

JNK inhibitor IX restrains pancreatic cancer through p53 and p21 [ Front Oncol, 2022, 12:1006131]	PubMed: 36568248
JNK inhibitor IX restrains pancreatic cancer through p53 and p21 [ Front Oncol, 2022, 12:1006131]	PubMed: 36568248
TLR7/8-agonist-loaded Nanoparticles Promote the Polarization of Tumour-Associated Macrophages to Enhance Cancer Immunotherapy [ Nat Biomed Eng, 2018, 2(8):578-588]	PubMed: 31015631

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.