Camizestrant (AZD9833)

Catalog No.S8958 Batch:S895801

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Technical Data

Formula

C24H28F4N6
Molecular Weight 476.51 CAS No. 2222844-89-3
Solubility (25°C)* In vitro DMSO 95 mg/mL (199.36 mM)
Ethanol 95 mg/mL (199.36 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.79mg/ml Taking the 1 mL working solution as an example, add 50 μL of 15.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
4.75mg/ml Taking the 1 mL working solution as an example, add 50 μL of 95 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Camizestrant (AZD9833) is an orally available and selective estrogen receptor (ER) antagonist with antineoplastic activity.
Targets
ER [1]
In vitro

AZD9833 is demonstrated to be a highly potent selective estrogen receptor degraders (SERD) that shows a pharmacological profile comparable to ICI-182780;in its ability to degrade ERα in both MCF-7 and CAMA-1 cell lines.[2]
In vivo

A stringent control of lipophilicity ensures that AZD9833 has favorable physicochemical and preclinical pharmacokinetic properties for oral administration. AZD9833 is potent in vivo activity in mouse xenograft models.[2]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    MCF-7 cells

  • Concentrations

    100 nM

  • Incubation Time

    24 h

  • Method

    MCF7 cells are treated with DMSO, 1 nM estradiol (E2), or 100 nM 4-OH ICI 46474, ICI-182780, or AZD9833 for 24 h. Expression of the ERα regulated genes PGR, TFF1, and GREB1 is assessed.
Animal Study:

[1]
  • Animal Models

    Male CB17 SCID mice, rats

  • Dosages

    0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg

  • Administration

    IV, Oral gavage

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.