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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C8H14ClN5 |
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| Molecular Weight | 215.68 | CAS No. | 1912-24-9 | ||||
| Solubility (25°C)* | In vitro | DMSO | 43 mg/mL (199.36 mM) | ||||
| In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Atrazine (Chromozin, Oleogesaprim, Aktikon, Gesaprim) is a selective triazine herbicide. This compound is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations. | |
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| Targets |
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| In vitro | Atrazine is a phosphodiesterase inhibitor and is classified as an estrogen disrupting compound because it elevates estrogen levels via induction of the enzyme aromatase. This compound exposure alters the function of innate immune cells such as NK cells, DC, mast cells, and macrophages, and significantly inhibited CD4+ T cell proliferation and accumulation as well as the expression of the activation markers CD25 and CD69 in a dose-dependent manner. | |
| In vivo | Atrazine is not acutely toxic and, owing to its relatively short half-life in the body, it does not bioaccumulate. However, adverse effects on fetal growth and development, male fertility, and the nervous and immune systems have been observed. In vivo, exposure to this chemical has been shown to decrease tumor resistance. |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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