ATP citrate lyase Rabbit Recombinant mAb

Catalog No.A5181

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Description

Specificity ATP citrate lyase Rabbit Recombinant mAb detects endogenous level of total ATP citrate lyase.
Background ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. ACLY is a cross-link between glucose and/or glutamine metabolism and fatty acid synthesis and/or mevalonate pathways. Acetyl CoA is an essential substrate for fatty acid synthesis and mevalonate pathways. ACLY is upregulated in several types of cancer cells and that, upon inhibition of ACLY, cancer cells undergo a proliferation arrest both in vivo and in vitro. ACLY plays an important role in regulating histone acetylation levels in diverse mammalian cell types. It is required for optimal proliferation, and simply increasing nuclear-cytosolic acetyl-CoA production is insufficient to fully replace ACLY.

Usage Information

Application WB,ELISA
Dilution
WB
1:1000
Reactivity Human Mouse Rat
MW (kDa) 122kDa
Source Rabbit
Concentration 1mg/ml
Storage buffer 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
Storage
(From the date of receipt)
Store at –20°C.

Application Data

WB

Validated by Selleck