ARN-19702

Catalog No.E0454 Batch:E045401

Print

Technical Data

Formula

C21H22FN3O3S2
Molecular Weight 447.55 CAS No. 1971937-18-4
Solubility (25°C)* In vitro DMSO 89 mg/mL (198.86 mM)
Ethanol 4 mg/mL (8.93 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ARN19702 is an orally active, reversible N-Acylethanolamine acid amidase(NAAA) inhibitor (IC50 on human NAAA = 230 nM) that produces remarkable protective effects against multiple sclerosis in mice.
Targets
NAAA [1]
0.23 μM
In vitro

ARN19702 is a selective, orally active, reversible and brain-penetrant N-acylethanolamine acid amidase (NAAA), by a non-covalent mechanism.[1]
In vivo

ARN-19702 attenuates the spontaneous nocifensive response elicited and the hypersensitivity in male mouse model of acute and neuropathic pain, also reduces nociception associated with paclitaxel-induced neuropathy without development of subacute antinociceptive tolerance in male rat model of acute and neuropathic pain.[2]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HEK293 cells

  • Concentrations

    --

  • Incubation Time

    2 h

  • Method

    Lysosomal extracts of hNAAA-overexpressing HEK293 cells are incubated with vehicle (2% DMSO), ARN-19702, for 2 h before addition of activity-based NAAA probe.
Animal Study:

[2]
  • Animal Models

    mouse and rat models of acute and neuropathic pain

  • Dosages

    3-10 mg/kg for male rats; 0.1-30 mg/kg for male mice

  • Administration

    p.o.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.