Arc Mouse mAb

Catalog No.: F3281

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Biological Description

Specificity Arc Mouse mAb recognizes endogenous levels of total Arc protein.
Background Arc (Activity-regulated cytoskeleton-associated protein), also known as Arg3.1, is an immediate early gene product essential for synaptic plasticity, learning, and memory. Structurally, Arc adopts a unique bi-lobar configuration homologous to the capsid domain of HIV Gag protein, reflecting its evolutionary origin from the Ty3/Gypsy retrotransposon family. It contains an N-terminal lobe with a hydrophobic pocket that mediates binding to key synaptic proteins such as CaMKII and TARPγ2 (Stargazin), which are crucial for AMPA receptor trafficking. Arc is highly expressed in glutamatergic neurons in response to synaptic activity and is enriched in dendrites and postsynaptic densities, where its tightly regulated mRNA is rapidly trafficked and locally translated. Functionally, Arc controls synaptic strength by regulating AMPA receptor endocytosis and contributes to both Hebbian and homeostatic plasticity, playing a critical role in memory consolidation and cognitive function.

Usage Information

Application WB, IP, IF, ELISA Dilution
WB IP IF
1:100-1:500 1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) 1:50-1:500
Reactivity Human, Mouse, Rat
Source Mouse MW 55 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

Application Data