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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C17H12ClFN6O3S |
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| Molecular Weight | 434.83 | CAS No. | 2752441-61-3 | |
| Solubility (25°C)* | In vitro | DMSO | 87 mg/mL (200.07 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | APL-4098 is an orally active, selective, ATP‑competitive GCN2 (EIF2AK4) inhibitor with Ki of 4.39 nM and Kd of 2.9 nM. APL‑4098 impairs mitochondrial function and triggers the mitochondrial unfolded protein response, leading to cytotoxicity in primary AML cells, including leukemia stem cells. |
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Protocol (from reference)
References
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