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Biological Description
| Specificity | Anti-TRIM56 Rabbit Antibody [P3H23] detetcts endogenous levels of total TRIM56 protein. |
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| Background | TRIM56, also known as Ring finger protein 109 (RNF109), is a member of the tripartite motif (TRIM) protein family that functions primarily as an E3 ubiquitin ligase, but also exhibits deubiquitinase activity and RNA-binding ability. It is a cytoplasmic protein of 755 amino acids encoded on chromosome 7, containing three conserved domains: an N-terminal RING domain, a B-box domain, and a coiled-coil domain, placing it in the C-V TRIM subfamily. TRIM56 expression is widespread in mammalian tissues and is strongly induced by type I interferons, linking it to antiviral defense. Functionally, TRIM56 regulates innate immune signaling by modulating the TLR and cGAS–STING pathways, thereby promoting interferon and cytokine production. It also exerts direct antiviral effects against diverse RNA and DNA viruses, and has context-dependent roles in cancer, acting as an oncogene in some tumors (e.g., breast cancer, glioma) and a tumor suppressor in others (e.g., ovarian, lung, liver cancers). This dual activity underscores its importance in both antiviral immunity and tumorigenesis. |
Usage Information
| Application | WB, IHC, IF, FCM | Dilution |
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| Reactivity | Human | ||||||||||
| Source | Rabbit | MW | 81 kDa | ||||||||
| Storage Buffer | PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3 | Storage (from the date of receipt) |
-20°C (avoid freeze-thaw cycles), 2 years | ||||||||
References
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