Anti-Sumo 1 Rabbit Antibody [G24F22]

Catalog No.: F1114

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Biological Description

Specificity Anti-Sumo 1 Rabbit Antibody [G24F22] detects endogenous levels of total Sumo 1 protein.
Background SUMO-1 (Small Ubiquitin-like Modifier 1) is a ubiquitin-related protein modifier that covalently attaches to target proteins through a process called sumoylation, thereby altering their stability, localization, and activity without generally targeting them for degradation. Structurally, SUMO-1 shares identity with SUMO-2/3 but lacks the lysine residues necessary for polyubiquitin-like chain formation, which gives it distinct regulatory functions. It is expressed in many tissues and localizes predominantly to the nucleus, where it modifies proteins involved in transcription, DNA repair, chromatin organization, and nuclear transport. A well-characterized function of SUMO-1 is its conjugation to RanGAP1, which promotes RanGAP1 localization to the nuclear pore complex, thereby ensuring efficient nuclear transport. More broadly, SUMO-1 regulates diverse cellular processes, including apoptosis, DNA damage response, and chromatin remodeling, highlighting its essential role as a dynamic regulator of gene expression and genome stability.

Usage Information

Application WB, IP, IHC, IF, FCM, ChIP Dilution
WB IP IHC IF FCM CHIP
1:1000 - 1:5000 1:20 1:250 1:250 - 1:500 1:20 - 1:100 1:5
Reactivity Human, Mouse, Rat
Source Rabbit MW 12 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

References

  • https://pubmed.ncbi.nlm.nih.gov/23328396/
  • https://pubmed.ncbi.nlm.nih.gov/9357311/

Application Data