Anti-SAE1 Rabbit Antibody [B2F24]

Catalog No.: F3862

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Biological Description

Specificity Anti-SAE1 Rabbit Antibody [B2F24] detects endogenous levels of total SAE1 protein.
Background SUMOylation, a post-translational modification involving the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to target substrates, plays a critical role in diverse cellular processes such as transcriptional regulation, protein stability, cell cycle control, and apoptosis. SAE1 (SUMO-activating enzyme subunit 1), a core component of the heterodimeric SUMO-activating enzyme complex, is indispensable for initiating SUMOylation. Elevated expression of SAE1 has been linked to the onset and progression of multiple cancers, including glioma, gastric cancer, and Myc-driven tumors. High SAE1 levels are frequently detected in a range of malignancies and show strong correlations with tumor initiation and progression. In hepatocellular carcinoma, SAE1 overexpression is associated with tumor metastasis, advanced disease stage, and unfavorable prognosis. Similarly, in colon cancer, SAE1 is markedly upregulated, and its inhibition triggers cell cycle arrest, apoptosis, and suppressed cellular proliferation. In glioma, increased SAE1 expression enhances cell proliferation and migration by promoting both SUMOylation and phosphorylation of protein kinase B (PKB/AKT), thereby driving glioma development in vitro and in vivo.

Usage Information

Application WB, IP, IF, FCM Dilution
WB IP IF FCM
1:10000 - 1:50000 1:50 - 1:70 1:500 1:230
Reactivity Human
Source Rabbit MW 38 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

References

  • https://pubmed.ncbi.nlm.nih.gov/39742381/
  • https://pubmed.ncbi.nlm.nih.gov/33477333/

Application Data