Anti-Peripherin Rabbit Antibody [P7B12]

Catalog No.: F3997

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Biological Description

Specificity Anti-Peripherin Rabbit Antibody [P7B12] detects endogenous levels of total Peripherin protein.
Background Peripherin is a class III intermediate filament protein primarily expressed in the peripheral nervous system, particularly in motor and sensory neurons. It plays a critical role in neurite outgrowth, axonal transport, and maintaining axonal stability during myelination. It consists of an α-helical rod domain flanked by non-helical N-terminal and C-terminal domains, which facilitate its assembly into filamentous networks characteristic of intermediate filaments. Multiple isoforms of peripherin arise from alternative splicing, affecting its filament assembly and overall neuronal health. Peripherin stabilizes the cytoskeleton, supports neurite extension, and aids in organelle transport by interacting with proteins like Rab7A and AP-3, which are involved in endosomal and lysosomal trafficking. Its expression is tightly regulated by signaling molecules such as nerve growth factor (NGF), interleukin-6, and leukemia inhibitory factor, via promoter elements and JAK-STAT pathways. Additionally, post-translational modifications, including phosphorylation, influence peripherin’s solubility and filament dynamics. Dysregulation and aggregation of peripherin are implicated in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and peripheral neuropathies.

Usage Information

Application WB, IP, IHC, IF , FCM Dilution
WB IP IHC IF FCM
1:1000 1:30 1:2000 1:100 1:50
Reactivity Mouse, Rat, Human
Source Rabbit MW 54 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

References

  • https://pubmed.ncbi.nlm.nih.gov/36499746/
  • https://pubmed.ncbi.nlm.nih.gov/39995075/

Application Data