Anti-mouse IL-6-InVivo [MP5-20F3]

Catalog No.A2118 Batch: A211810

Clone No.MP5-20F3

Anti-mouse IL-6-InVivo monoclonal antibody (Clone:MP5-20F3) can reacts with mouse IL-6 (interleukin-6) which is a 21-28 kDa cytokine that is expressed by many cell types, including T lymphocytes, B lymphocytes, monocytes, fibroblasts, and endothelial cells. Anti-mouse IL-6-InVivo has been shown to neutralize the bioactivity of natural or recombinant IL-6.

Technical Data

Formulation	PBS Buffer, PH 7.4
Clone	MP5-20F3
Immunogen	Recombinant mouse IL-6
Isotype	Rat IgG1, κ
Application	in vivo IL-6 neutralization
Source	CHO
Murine Pathogen Screening Panel	all targets tested yielded Negative Results: Theiler’s Murine Encephalomyelitis Virus, Ectromelia (Mousepox) Virus, Hantavirus, Polyomavirus, Sendai Virus, Mycoplasma pulmonis, Pneumonia Virus of Mice, K Virus, Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Norovirus, Mouse Minute Virus, Mouse Cytomegalovirus, Mouse Adenovirus, Lactate Dehydrogenase-Elevating Virus, Reovirus Panel, Lymphocytic Choriomeningitis Virus, Mouse Rotavirus.
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Sterility	5.85 mg/mL
Purity	99%
Protein concentration	5.85 mg/mL
Endotoxin Level	＜1EU/mg

Customer Product Validation

Selleck's Anti-mouse IL-6-InVivo [MP5-20F3] Has Been Cited by 25 publications

Targeting RPE Senescence Via Suppressing IL-6/IL-6R Signaling for Treating Retinal Degenerative Diseases [ Investigative Ophthalmology & Visual Science, September 2025, Vol.66, 44]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40970669
Targeting RPE Senescence Via Suppressing IL-6/IL-6R Signaling for Treating Retinal Degenerative Diseases [ Investigative Ophthalmology & Visual Science, September 19, 2025, 66(12):44]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40970669
Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity [ Communications Biology, October 21, 2025, 8(1):1488]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41120657
Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation [ Nature Communications, November 26, 2025, 16(1):10576]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41298450
Oncolytic virus-induced IL-1β+ monocyte-IL-6+ CAF axis suppresses dendritic cell-mediated antitumor immunity in pancreatic cancer [ Journal for Immunotherapy of Cancer, November 1, 2025, 13(11):e013175]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41253490
SR-717, a Non-Nucleotide STING Agonist, Displayed Anti-Radiation Activity in a IL-6 Dependent Manner [ The FASEB Journal, May 31, 2025, 39(11):e70644]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40448435
Targeting CD177: A Novel Therapeutic Strategy for NLRP3-Associated Autoinflammatory Diseases [ International Journal of Molecular Sciences, March 20, 2026, 27(6):2841]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41898699
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety [ Immunity, March 1, 2024, 57(3):495-512.e11]	https://www.ncbi.nlm.nih.gov/pubmed/?term=38395698
The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production [ The Journal of Biological Chemistry, June 1, 2024, 300(6):107376]	https://www.ncbi.nlm.nih.gov/pubmed/?term=38762176
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway [ Nature Communications, January 3, 2025, 16(1):289]	https://www.ncbi.nlm.nih.gov/pubmed/?term=39753529

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.