Anti-mouse IFNγ-InVivo [R4-6A2]

Catalog No.A2105        Batch: A210503

       Clone No.R4-6A2

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The R4-6A2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) which is a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNγ.

Technical Data

Formulation PBS buffer, pH 7.0
Clone R4-6A2
Immunogen Partially-purified native mouse IFNγ
Isotype Rat IgG1,κ
Application in vivo/vitro IFNγ neutralization
Source CHO
Murine Pathogen Screening Panel all targets tested yielded Negative Results: Theiler’s Murine Encephalomyelitis Virus, Ectromelia (Mousepox) Virus, Hantavirus, Polyomavirus, Sendai Virus, Mycoplasma pulmonis, Pneumonia Virus of Mice, K Virus, Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Norovirus, Mouse Minute Virus, Mouse Cytomegalovirus, Mouse Adenovirus, Lactate Dehydrogenase-Elevating Virus, Reovirus Panel, Lymphocytic Choriomeningitis Virus, Mouse Rotavirus.
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Sterility 3.37mg/ml
Purity 99%
Protein concentration 3.37mg/ml
Endotoxin Level <1 EU/mg

Customer Product Validation

Verified customer review of Anti-mouse IFNγ-InVivo [R4-6A2]

Verified customer review of Anti-mouse IFNγ-InVivo [R4-6A2]

Data from [Data independently produced by , ]

Selleck's Anti-mouse IFNγ-InVivo [R4-6A2] Has Been Cited by 16 publications

SOD3 suppresses early cellular immune responses to parasite infection [ Nature Communications, June 8, 2024, 15(1):4913]

https://www.ncbi.nlm.nih.gov/pubmed/?term=38851821
The IL-17A/Neutrophil axis plays a critical role in lethal infection induced by an emerging ultra-virulent Streptococcus suis serotype 5 strain [ Virulence, June 21, 2026, 17(1)]

https://www.ncbi.nlm.nih.gov/pubmed/?term=42308351
The IL-17A/Neutrophil axis plays a critical role in lethal infection induced by an emerging ultra-virulent Streptococcus suis serotype 5 strain [ Virulence, June 21, 2026, 2690810]
Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer [ Journal for Immunotherapy of Cancer, July 1, 2025, 13(7):e011948]

https://www.ncbi.nlm.nih.gov/pubmed/?term=40664447
Xbp1 controls the reparative function of intestinal ILC2s during colitis [ Journal of Experimental Medicine, January 5, 2026, e20250440]

https://www.ncbi.nlm.nih.gov/pubmed/?term=41165618
Activation of T Cell-Intrinsic p53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherapy [ Cancer Discovery, January 12, 2026, 155-176]

https://www.ncbi.nlm.nih.gov/pubmed/?term=40970761
Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors [ Phytomedicine, January 1, 2025, 136:156224]

https://www.ncbi.nlm.nih.gov/pubmed/?term=39642461
Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects [ Cell Communication and Signaling : CCS, February 19, 2025, 23(1):99]

https://www.ncbi.nlm.nih.gov/pubmed/?term=39972350
Clostridium scindens attenuates acute kidney injury by producing indole-3-acetic acid [ npj Biofilms and Microbiomes, December 15, 2025, 16]

https://www.ncbi.nlm.nih.gov/pubmed/?term=41397986
Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner [ Cell Reports, 2026-08, 117745]

https://www.ncbi.nlm.nih.gov/pubmed/?term=42531132

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.