Anti-mouse IFNAR-1-InVivo [MAR1-5A3]

Catalog No.A2121 Batch: A212109

Clone No.MAR1-5A3

Anti-mouse IFNAR-1-InVivo monoclonal antibody (Clone: MAR1-5A3) reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). Anti-mouse IFNAR-1-InVivo has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.

Technical Data

Formulation	PBS Buffer, PH 7.4
Clone	MAR1-5A3
Immunogen	Extracellular domain of mouse IFNAR-1
Isotype	Mouse IgG1, κ
Application	in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB
Source	CHO
Murine Pathogen Screening Panel	all targets tested yielded Negative Results: Theiler’s Murine Encephalomyelitis Virus, Ectromelia (Mousepox) Virus, Hantavirus, Polyomavirus, Sendai Virus, Mycoplasma pulmonis, Pneumonia Virus of Mice, K Virus, Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Norovirus, Mouse Minute Virus, Mouse Cytomegalovirus, Mouse Adenovirus, Lactate Dehydrogenase-Elevating Virus, Reovirus Panel, Lymphocytic Choriomeningitis Virus, Mouse Rotavirus.
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Sterility	6.87 mg/ml
Purity	99%
Protein concentration	6.87 mg/ml
Endotoxin Level	<1EU/mg

Customer Product Validation

Selleck's Anti-mouse IFNAR-1-InVivo [MAR1-5A3] Has Been Cited by 13 publications

SBRT embedded in low-dose RT plus αPD-1 (immuno-EclipseRT, iERT) elicits CD8+ T cell immunity against bulky tumors via an IFN-I/NK/DC axis [ Nature Communications, July 8, 2026, 17(1):7568]	https://www.ncbi.nlm.nih.gov/pubmed/?term=42420294
Targeting IFN-I driven tertiary lymphoid structures halts B cell-mediated bone loss in periodontitis [ International Journal of Oral Science, July 27, 2026, 18(1):53]	https://www.ncbi.nlm.nih.gov/pubmed/?term=42503518
Type I IFN Dynamics Define an Early Checkpoint for Survival and Orchestrate Systemic Neutrophil Heterogeneity in Lethal Viral Infection [ nan, January 24, 2026, nan]
Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner [ Cell Reports, January 1, 2023, 42(1):112002]	https://www.ncbi.nlm.nih.gov/pubmed/?term=36662617
Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects [ Cell Communication and Signaling, February 19, 2025, 23(1):99]	https://www.ncbi.nlm.nih.gov/pubmed/?term=39972350
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition [ Immunity, February 1, 2026, 59(2):458-476.e13]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41619730
sVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage [ EMBO Reports, August 11, 2025, 26(18):4477-4502]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40789964
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone [ Signal Transduction and Targeted Therapy, April 25, 2022, 7(1):137]	https://www.ncbi.nlm.nih.gov/pubmed/?term=35468896
Targeting immune cells in the aged brain with engineered proteins reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition [ Immunity, 2026 Jan 30, 59(2):458–476.e13]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41619730
Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects [ Cell Commun Signal, 2025, 23(1):99]	https://www.ncbi.nlm.nih.gov/pubmed/?term=39972350

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.